Multi-omics Study for Early Detection of Colorectal Cancer Based on Liquid Biopsy Technology
The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical performance externally.
• Aged over 18 years.
• Participants confirmed with colorectal adenocarcinoma or advanced adenoma through colonoscopy and pathological examination.
• Provision of informed consent prior to any study specific procedures, sampling, and analyses.
• Individuals of General risk arm should meet all the following criteria:
‣ No history of colorectal adenomas or sessile serrated polyps.
⁃ No history of inflammatory bowel disease (8-10 years ).
⁃ No family history (first-degree relatives) of colorectal cancer.
• Individuals of High-risk arm should meet at least one of the following criteria:
‣ Asia-Pacific Colorectal Screening (APC) score ≥ 3.
⁃ Family history (first-degree relatives) of colorectal cancer.
⁃ History of positive fecal occult blood test.
⁃ Any 2 of the following: chronic diarrhea, chronic constipation, mucous bloody stools, history of psychological stimulation, history of chronic appendicitis or appendectomy, history of chronic biliary disease or cholecystectomy.
⁃ Individuals with inflammatory bowel disease.
• All participants must be confirmed not to have colorectal malignancy or advanced adenomas through colonoscopy.
• Provision of informed consent prior to any study specific procedures, sampling, and analyses.